Edmund Czerwinski, Ph.D.
Associate Professor
Telephone: (409) 772-3287
Fax: (409) 747-4745
E-mail:ewczerwi@utmb.edu
Campus Location: 625 Basic Science Building
Mail Route: 0647
Research
I have been collaborating with Prof. Jim Lee in his studies of elucidating the pathway by which allosteric enzymes communicate.We are engaged in determining the three-dimensional structures of the pyruvate kinase mutants using x-ray crystallography.We have solved the structure of the S402P mutant at 2.8 ‰.Crystallographic studies of other pyruvate kinase mutants are underway. This laboratory has been engaged in collaborative
efforts to determine the x-ray crystallographic structures of small molecules which have some biological importance. These compounds include a series of alkyl-substituted triphenylphosphonium compounds, some of which are thought to have a role in affecting the life cycle of the schistosome parasite.We have also been engaged in determining the crystal structure of steroidal compounds. Among these compounds is the glucocorticoid cortivazol and several estradiols.